Valvular & structural heart disease
Transcarotid Versus Surgical Aortic Valve Replacement for the Treatment of Severe Aortic Stenosis
Authors' conclusion
TC-TAVR was associated with improved 30-day clinical outcomes compared with SAVR, with no significant differences in death, stroke, and hospitalization at 1-year follow-up. These findings suggest that TC-TAVR may be a valid alternative to SAVR in nontransfemoral-TAVR candidates.
Study context
- Population
- Patients with severe aortic stenosis undergoing transcarotid TAVR or surgical aortic valve replacement182 patients propensity-matched and included in each group · SAVR 352 · TC-TAVR 434
- Participants
- 786 patients
- Comparison
- TC-TAVR and SAVR patients with severe aortic stenosis in a propensity-matched population
- TC-TAVRn = 182reference
- SAVRn = 182
- Outcome
- Composite of:
- Death from any cause
- Stroke/transient ischemic attack
- Procedure-related or valve-related hospitalization
- Follow-up
- 30 days and 1 year
Methodological detailsdata prospectively collected in dedicated databases, clinical events defined according to Valve Academic Research Consortium-3 criteria
- Data prospectively collected in dedicated databases
- Clinical events defined according to Valve Academic Research Consortium-3 criteria
Main finding
As reported in the abstract
SAVR
- 30 days
- 12.6%
- 1 year
- 19.7%
TC-TAVR
- 30 days
- 4.3%
- 1 year
- 12.7%
30 days
SAVR12.6%
TC-TAVR4.3%
1 year
SAVR19.7%
TC-TAVR12.7%
SAVR vs TC-TAVRHazard ratio (95% CI)
30 days; higher rate with SAVR
2.93(1.45–5.94)
1 year; no significant differences between groups
1.63(0.98–2.73)
Further findings
Baseline characteristics of matched population
- Mean age
- 75 years
- Mean Society for Thoracic Surgeons score
- 3.6%
- Baseline characteristics well balanced between the matched groups
Safety
Acute kidney injury stages 2 to 4, bleeding events, and new-onset atrial fibrillation · hospital period
- Occurred more often in the SAVR group
- P < 0.001
Vascular complications and need for permanent pacemaker implantation
- Vascular complications more often in the TC-TAVR group
- P = 0.01
- Permanent pacemaker implantation more often in the TC-TAVR group
- P = 0.001
Original publication
Transcarotid Versus Surgical Aortic Valve Replacement for the Treatment of Severe Aortic Stenosis. Circ Cardiovasc Interv. Published 26 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →