Valvular & structural heart disease
Transcatheter Aortic Valve Implantation for Combined Aortic and Mitral Stenoses: Insights from the OCEAN-TAVI Registry
Authors' conclusion
In patients undergoing TAVI for severe AS, those with moderate or severe MS experienced worse outcomes after TAVI compared with those without MS.
Study context
- Population
- Patients undergoing transcatheter aortic valve implantation (TAVI) for severe aortic stenosis (AS) in the OCEAN-TAVI registry
- Participants
- 106 vs 6,570
- Exposure
- Mitral stenosis (MS) vs no MS in patients undergoing TAVI for severe AS
- MSn = 106
- Controlsn = 6,570reference
- Outcome
- Composite of:
- All-cause death
- Admission for HF
- Follow-up
- Median 2.1 years
Methodological detailsOCEAN-TAVI registry, propensity score matched analysis
- OCEAN-TAVI registry
- Propensity score matched analysis
Main finding
As reported in the abstract
Composite of:
- All-cause death
- HF admission
MS vs ControlsAdjusted hazard ratio (95% CI)P value
Composite of all-cause death and HF admission
1.84(1.34–2.51)
P < 0.01Propensity score matched analysis
1.91(1.14–3.22)
P < 0.01Observational data: associations, not effects.
Further findings
30-day mortality
P = 0.18
Early composite outcomes
P = 0.56
Adverse events by moderate or severe mitral annulus calcification (MAC) (MS subgroup)
| Adjusted HR (95% CI) | P value | ||
|---|---|---|---|
| Moderate or severe MAC | 2.89 (1.20–6.99) | P = 0.018 | |
| 0.10.31310Adjusted hazard ratio (log scale) |
NYHA class 3 or 4 (MS) · baseline and 1 year after TAVI
- NYHA class 3 or 4 at baseline
- 56%
- NYHA class 3 or 4 at 1 year
- 6%
Adverse events by moderate or severe MAC (MS subgroup)
- Transmitral gradient (TMG) and mitral valve area (MVA) did not contribute to increased risk
Original publication
Transcatheter Aortic Valve Implantation for Combined Aortic and Mitral Stenoses: Insights from the OCEAN-TAVI Registry. ESC Heart Fail. Published 21 August 2024. doi:10.
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