Valvular & structural heart disease
Differentiating Left Ventricular Remodeling in Aortic Stenosis From Systemic Hypertension
Authors' conclusion
Unique remodeling signatures might differentiate the etiology of LV hypertrophy.
Study context
- Population
- Severe aortic stenosis (AS) before and after surgical aortic valve replacement, hypertension (HTN) and healthy controls undergoing cine CMR
- Participants
- 91 participants109 CMR scans
- Exposure
- Severe AS vs HTN vs healthy controls
- Severe ASn = 36
- HTNn = 19
- Healthy controlsn = 36reference
- Outcome
- 3D LV geometric remodeling (principal component analysis at end-diastole)
Main finding
As reported in the abstract
Combined 3 features discriminating AS from HTN, AUC
0.792
Observational data: associations, not effects.
Further findings
Left ventricular (LV) left-right axis shift after aortic valve replacement (CMR at 8 months, n=18)
- Predictive of postoperative LV mass regression
- R2=0.339, P=0.014
- Not reversible post-aortic valve replacement; no association with strain, age or sex
Original publication
Differentiating Left Ventricular Remodeling in Aortic Stenosis From Systemic Hypertension. Circ Cardiovasc Imaging. Published 20 August 2024. doi:10.
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