Valvular & structural heart disease
Transcatheter Edge-to-Edge Repair in Secondary Mitral Regurgitation With Extended Non–COAPT-Like Features: From the EXPANDed Studies
Authors' conclusion
In the EXPANDed studies, non-COAPT-like patients experienced significant improvements in MR, HFH, and quality-of-life at 1 year, comparable with those observed in COAPT-like patients.
Study context
- Population
- Patients with secondary mitral regurgitation treated with 3rd/4th-generation MitraClip mitral transcatheter edge-to-edge repair (MTEER)Secondary mitral regurgitation (SMR) patients of 2,205 in EXPANDed
- Participants
- 967 patients
- Comparison
- MTEER in non-COAPT-like vs COAPT-like SMR patients
- COAPT-liken = 197reference
- Non-COAPT-liken = 81
Methodological detailsglobal, echocardiographic core laboratory
- Global
- Echocardiographic core laboratory
Primary result
As reported in the abstract
One-year mortality and HFH · 1 year
- One-year mortality and heart failure hospitalizations (HFH) rates similar between groups
Further findings
HFH reduction from pre- to post-MTEER
MR ≤1+ · 1 year
Original publication
Transcatheter Edge-to-Edge Repair in Secondary Mitral Regurgitation With Extended Non–COAPT-Like Features: From the EXPANDed Studies. JACC Heart Fail. Published 27 June 2025. doi:10.
Summarised from the published abstract; every number is checked against it