Valvular & structural heart disease
Transcatheter Tricuspid Valve Annuloplasty vs Edge-to-Edge Repair: A Propensity-Matched Multicenter Comparative Analysis
Authors' conclusion
In patients with severe secondary TR and sufficient clinical and anatomical overlap for matched comparison, T-TEER showed a more favorable safety profile and more effective, durable TR reduction, whereas early clinical outcomes at 1 year were comparable after adjustment for baseline differences, highlighting the need for longer-term evaluation.
Study context
- Population
- Patients with severe secondary tricuspid regurgitation (TR) treated with TV transcatheter edge-to-edge repair (T-TEER) or transcatheter TV annuloplasty (TTVA)T-TEER 882 · TTVA 240
- Participants
- 1,122 patients · 111 well-balanced matched pairs
- Comparison
- T-TEER vs TTVA
- T-TEERn = 882
- TTVAn = 240
Methodological details1:1 propensity-score matching, consecutive patients (2017-2024)
- 1:1 propensity-score matching
- Consecutive patients (2017-2024)
Main finding
As reported in the abstract
Residual TR ≤ 1+ and ≤2+ · At discharge
TR ≤ 1+
TR ≤2+
Further findings
| Outcome | T-TEER | TTVA |
|---|---|---|
| Freedom from all-cause mortality or first heart failure hospitalization · 1-year | 75.0% (95% CI 66.8–84.1) | 79.8% (95% CI 72.4–87.9) |
- Freedom from all-cause mortality or first heart failure hospitalization: P = 0.408
≥2-grade reduction · At discharge
- Comparable
Symptomatic improvement and reintervention rates · within 1 year
- Similar between groups
Safety
Any procedural complication
- Any procedural complication: P < 0.001
Original publication
Transcatheter Tricuspid Valve Annuloplasty vs Edge-to-Edge Repair: A Propensity-Matched Multicenter Comparative Analysis. JACC Adv. Published 21 July 2026. doi:10.
Summarised from the published abstract; every number is checked against it