Valvular & structural heart disease

Transcatheter Tricuspid Valve Intervention Risk Scores: Assessment in an International Multicenter Cohort

JACC Cardiovasc IntervPublished Retrospective cohort study

Authors' conclusion

The currently available TTVI risk scores derived from surgical or early TTVI cohorts may not be well suited for accurate risk assessment in contemporary TTVI. The surgical scores when applied to TTVI are miscalibrated, and the TRIVALVE score lacks discrimination.

Study context

Population
Patients undergoing transcatheter tricuspid valve intervention (TTVI) (tricuspid TEER, transcatheter tricuspid valve replacement or annuloplasty), 2019–2024
Participants
457 patients6 international centres
Exposure
TTVI risk scores (TRI-SCORE) vs STS-TR vs TRIVALVE risk scores
Outcome
Discrimination (C statistic) and calibration of each score for its endpoint
Methodological detailsmulticentre, 6 international centres, risk score validation
  • Multicentre
  • 6 international centres
  • Risk score validation

Main finding

As reported in the abstract

Risk score performance
GroupAUCObserved-to-expected mortality ratio
TRIVALVE0.609
TRI-SCORE0.13 (95% CI: 0.07-0.23)
STS-TR0.35 (95% CI: 0.19-0.60)

AUC

TRIVALVE0.609
TRI-SCORE— not stated in the abstract
STS-TR— not stated in the abstract

Observed-to-expected mortality ratio

TRIVALVE— not stated in the abstract
TRI-SCORE0.13 (95% CI: 0.07-0.23)
STS-TR0.35 (95% CI: 0.19-0.60)

Observational data: associations, not effects.

Original publication

Transcatheter Tricuspid Valve Intervention Risk Scores: Assessment in an International Multicenter Cohort. JACC Cardiovasc Interv. Published 23 March 2026. doi:10.1016/j.jcin.2025.12.020

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