Valvular & structural heart disease

Transcatheter valve-in-valve versus redo-surgical valve replacement for mitral bioprosthetic valve dysfunction: rationale and design of the SURVIV randomised trial

EuroInterventionPublished investigator-initiated, prospective, multicentre, open-label, randomised controlled trial

Study context

Population
Patients with mitral bioprosthetic valve dysfunction (BVD) suitable for surgical redo-mitral valve replacement (rMVR) or transcatheter mitral valve-in-valve (mViV)planned enrolment
Participants
150 patients
Planned comparison
Transcatheter mViV vs surgical rMVR for mitral BVD
Primary endpoint
Composite of:
  • All-cause mortality
  • Disabling stroke
Follow-up
12 months

No results yet. This paper sets out the design of a trial; its results are to come.

Original publication

Transcatheter valve-in-valve versus redo-surgical valve replacement for mitral bioprosthetic valve dysfunction: rationale and design of the SURVIV randomised trial. EuroIntervention. Published 16 March 2026. doi:10.4244/eij-d-25-01090

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