Heart failure & cardiomyopathies
Transcoronary Study of Biomarkers in Patients with Heart Failure: Insights Into Intracardiac Production
Authors' conclusion
This study provided evidence of transcoronary changes in BNP, Gal-3 and TIMP-1 levels in HF patients, offering insights into their intracardiac production.
Study context
- Population
- Patients with heart failure (HF) and non-HF controls; HF canine model
- Participants
- 30 vs 10
- Comparison
- Femoral artery (FA) vs coronary sinus (CS) biomarker levels in HF patients vs non-HF controls
- HFn = 30
- Controln = 10reference
- Outcome
- Transcoronary gradients (FA vs CS) of BNP, Gal-3, sST2, TIMP-1, GDF-15 and myeloperoxidase (MPO)
Methodological detailstranscoronary sampling, HF canine model
- Transcoronary sampling
- HF canine model
Main finding
As reported in the abstract
Transcoronary gradients in HF (FA vs CS)
- Transcoronary gradients only for BNP, Gal-3 and TIMP-1 in HF
- CS vs FA: P = 0.005
- CS vs FA: P = 0.002
- CS vs FA: P = 0.001
Further findings
Biomarker levels, HF vs control
- All detected biomarkers significantly elevated in HF
Cardiac tissue expression (canine model, quantitative PCR (qPCR) and western blot (WB))
- Significant elevation of BNP, Gal-3 and TIMP-1 in HF cardiac tissue vs other groups
Original publication
Transcoronary Study of Biomarkers in Patients with Heart Failure: Insights Into Intracardiac Production. ESC Heart Fail. Published 27 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →