Heart failure & cardiomyopathies
The Transcriptional Profile of Iron Deficiency in Patients with Heart Failure: Heme-Sparing and Reduced Immune Processes
Authors' conclusion
Iron deficiency is associated with the preservation of heme-related processes at the cost of iron-sulfur clusters. Immune processes are downregulated, uncovering another high energy demand system affected.
Study context
- Population
- Patients with heart failure (HF) from the BIOSTAT-CHF cohort
- Participants
- 881 patients
- Comparison
- Iron deficiency (ID) vs non-ID
- IDn = 554
- Outcome
- Differentially expressed genes, ID vs non-ID
Methodological detailstranscriptome profiling in whole blood, in vitro stem cell-derived cardiomyocyte ID model
- Transcriptome profiling in whole blood
- In vitro stem cell-derived cardiomyocyte ID model
Main finding
As reported in the abstract
ID
62.9%
554
- Differentially expressed genes between ID and non-ID
- 89
- Upregulated genes
- 60
- Downregulated genes
- 29
Further findings
Mortality in HF by SIAH2 and CLIC4 expression
| HR (95% CI) | P value | ||
|---|---|---|---|
| SIAH2 | 2.40 (1.86–3.11) | P < 0.001 | |
| CLIC4 | 1.78 (1.53–2.07) | P < 0.001 | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
The Transcriptional Profile of Iron Deficiency in Patients with Heart Failure: Heme-Sparing and Reduced Immune Processes. Eur J Heart Fail. Published 26 December 2024. doi:10.
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