Transcriptomic biomarkers related to cardiac disease in childhood cancer survivors: a case-control study
Authors' conclusion
Using high-dimensional data selection methods has enabled the identification of the gene NFE2L2, associated with CD and HF in CCS.
Study context
- Population
- Childhood cancer survivors
- Participants
- 330 survivors
- Comparison
- CD cases vs CD-free controls
- Casesn = 165
- Controlsn = 165reference
- Outcome
- Transcriptomic biomarkers (expression of 8557 genes) associated with CD and HF
Methodological detailsmatched
- Matched
Main finding
As reported in the abstract
NFE2L2 expression (sole gene in final selection), lower in cases than controls
OR
- CD
- .16 (95% CI .09-.29)
- Heart failure (HF)
- .11 (95% CI .03-.37)
Observational data: associations, not effects.
Further findings
Interaction between treatment doses and NFE2L2 expression
- No interaction found
Discrimination of prognostic models with NFE2L2 vs clinical and treatment variables only
- CD: AUC with NFE2L2 vs without
- .85 vs .66
- HF: AUC with NFE2L2 vs without
- .87 vs .77
Original publication
Transcriptomic biomarkers related to cardiac disease in childhood cancer survivors: a case-control study. Eur Heart J. Published 23 September 2025. doi:10.
Summarised from the published abstract; every number is checked against it