Heart failure & cardiomyopathies
Transpulmonary Proteome Gradients Identify Pathways Involved in Pulmonary Vascular Disease Due To Heart Failure
Authors' conclusion
The lungs of patients with HF with high PVR display abnormal uptake and release of proinflammatory cytokines from IL6/gp130 family (IL6, IL33, oncostatin-M), along with increased transpulmonary uptake of GDF2/BMP9.
Study context
- Population
- Patients with HFrEF undergoing pulmonary artery catheterization, and controls160 HFrEF, 21 controls
- Participants
- 21 / 40 / 40
- Comparison
- High pulmonary vascular resistance (PVR) vs low PVR HFrEF vs controls
- Controlsn = 21reference
- Q1n = 40
- Q4n = 40
- Outcome
- Transpulmonary gradients of proteins (Olink proximity extension assay, 275 proteins) to identify mediators of PVD
Main finding
As reported in the abstract
High PVR heart failure (HF): significant transpulmonary uptake of proteins, mostly inflammation-associated (chemokines, oncostatin-M, MMP9) or TGF/activin pathway (GDF2/BMP9)
18
High PVR HF: release of proteins, notably IL6 and IL33
5
Original publication
Transpulmonary Proteome Gradients Identify Pathways Involved in Pulmonary Vascular Disease Due To Heart Failure. Circ Heart Fail. Published 23 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →