Heart failure & cardiomyopathies
Shedding Light on Latent Pulmonary Vascular Disease in Heart Failure With Preserved Ejection Fraction
Authors' conclusion
The results suggest that when CO is measured by direct Fick, few HFpEF patients have isolated latent PVD (ie, normal PVR at rest, becoming abnormal during exercise). HFpEF-latentPVD patients present with CO limitation to exercise, associated with dynamic tricuspid regurgitation, altered ventilatory control, and pulmonary vascular hyperreactivity, portending a poor prognosis.
Study context
- Population
- Heart failure with preserved ejection fraction (HFpEF) patients who underwent supine exercise right heart catheterization with CO by direct Fick, 2016–2021
- Participants
- 86 patients
- Exposure
- HFpEF-latentPVD vs HFpEF control
- Outcome
- Prevalence of HFpEF-latentPVD (exercise PVR >1.74 WU) among HFpEF patients
Main finding
As reported in the abstract
HFpEF patients qualifying as HFpEF-latentPVD
21%
HFpEF-latentPVD with pulmonary vascular resistance (PVR) >2 WU at rest
78%
Observational data: associations, not effects.
Further findings
Event-free survival
- Reduced in HFpEF-latentPVD
- P < 0.05
Baseline characteristics
- HFpEF-latentPVD older, higher pretest probability of HFpEF, more AF and at least moderate tricuspid regurgitation
- P < 0.05
Original publication
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