Valvular & structural heart disease
Tricuspid Right Ventricular Lead Entrapment in Transcatheter Tricuspid Interventions: The Tri-LEAD Study
Authors' conclusion
T-TEER has no detrimental impact on the performance of transvenous RV leads in the short term or midterm.
Study context
- Population
- Patients who underwent tricuspid transcatheter edge-to-edge repair (T-TEER) with an right ventricular (RV) lead in situ, 2015–2023
- Participants
- 146 patients
- Outcome
- RV lead dysfunction after T-TEER (change in RV lead function, dislodgement or fracture) and need for intervention due to RV lead dysfunction or cardiac complication
- Follow-up
- 2 years
Methodological detailsmulticentre, international
- Multicentre
- International
Main finding
As reported in the abstract
RV lead dysfunction · median follow-up 557 days (Q1-Q3: 278-966 days)
Impedance change >200 Ω
10
6.8%
Threshold change ≥1 V
2
1.4%
RV lead fracture, dislodgement, cardiac structure perforation or pacemaker-related re-interventions
0
T-TEER not associated with increased risk of composite safety endpoint
1.39; 0.64 to 3.02; P = 0.41 (adjusted SHR; 95% CI)
Observational data: associations, not effects.
Further findings
Change in RV lead parameters over time
- Sensing
- −0.53 mV/year; −1.15 to 0.08; P = 0.094 (95% CI)
- Impedance
- −2.4 Ω/year; −15.4 to 10.6; P = 0.72 (95% CI)
- Threshold
- −0.011 V/year; −0.052 to 0.031; P = 0.62 (95% CI)
- Minimal and not clinically significant
Original publication
Tricuspid Right Ventricular Lead Entrapment in Transcatheter Tricuspid Interventions: The Tri-LEAD Study. JACC Clin Electrophysiol. Published 18 December 2025. doi:10.
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