Valvular & structural heart disease
Tricuspid transcatheter edge-to-edge repair for tricuspid valve regurgitation: a sex-based real-world analysis from the TRI-SPA registry
Authors' conclusion
In a real-world setting, T-TEER was equally safe and effective in both sexes, achieving comparable procedural success and durable TR reduction.
Study context
- Population
- Patients who underwent tricuspid transcatheter edge-to-edge repair (T-TEER) for severe tricuspid regurgitation (TR) between June 2020 and May 2023 in Spainmean age 75.5 ± 9.1 years, 70% were females
- Participants
- 310 patients
- Exposure
- Outcomes were compared by sex.
- Outcome
- Composite of:
- All-cause mortality
- Heart failure-related hospitalization
- Tricuspid valve re-intervention
- Follow-up
- 12 months
Methodological detailsreal-world
- Real-world
Main finding
As reported in the abstract
Males
27.5
absolute event rate · %
Females
16.3%
absolute event rate
- Adjusted HR (groups' order not stated)
- 0.61, 95% CI: 0.31-1.18; p = 0.142
Observational data: associations, not effects.
Secondary outcomes
Coronary artery disease (baseline)
RV fractional area change (baseline)
Procedural success
Sustained TR reduction (grade ≤2+) · 12 months
Left atrial volume (baseline)
- Coronary artery disease (baseline): p < 0.001
- Right ventricular (RV) fractional area change (baseline): p < 0.001
- Left atrial volume (baseline): p = 0.038
- Procedural success: p = 0.71
- Sustained TR reduction (grade ≤2+): p = 0.40
Functional improvement (NYHA I/II class) · 12 months
- NYHA I/II class
- 75.0 vs. 82.3%
- p = 0.78
- Group order not stated
Original publication
Tricuspid transcatheter edge-to-edge repair for tricuspid valve regurgitation: a sex-based real-world analysis from the TRI-SPA registry. Eur Heart J Qual Care Clin Outcomes. Published 29 August 2025. doi:10.
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