Aortic & peripheral vascular disease
Two-Year Outcomes of the Prospective THRILLER Registry on Popliteal and Infrapopliteal Endovascular Interventions for Chronic Limb-threatening Ischemia (CLTI)
Authors' conclusion
Endovascular revascularization for popliteal and infrapopliteal disease in patients with CLTI is safe and effective in preventing limb loss and mortality at 2 years, although patients with Rutherford 6 limbs face significantly worse outcomes, particularly in the first 3 months.
Study context
- Population
- Patients with chronic limb-threatening ischemia (CLTI) undergoing popliteal or infrapopliteal endovascular revascularizationpatients, 1,119 interventions in 1,060 limbs, treating 551 popliteal, 1,352 tibial, and 239 pedal lesions, 78.4% (831/1,060) of limbs Rutherford 5, 8.1% (86/1,060) Rutherford 6, 41.3% (382/926) WIfI stage 4
- Participants
- 938 patients
- Exposure
- Rutherford 6 vs Rutherford 5 limbs
- Rutherford 6n = 86
- Rutherford 5n = 831reference
- Outcome
- Limb salvage and amputation-free survival (AFS)
- Follow-up
- 24 months
Methodological detailsconsecutive patients, seven Dutch hospitals
- Consecutive patients
- Seven Dutch hospitals
Main finding
As reported in the abstract
Hazard ratio (95% CI)P value
Rutherford 6 vs Rutherford 5limb salvage; significantly worse with Rutherford 6
3.07 (1.89–4.99), event not clearly stated
P < 0.001Rutherford 6 vs Rutherford 5AFS; significantly worse with Rutherford 6
2.07 (1.50–2.86), event not clearly stated
P < 0.001Rutherford 6 vs Rutherford 4AFS, first 3 months
14.13 (4.94–40.38), event not clearly stated
P < 0.001Observational data: associations, not effects.
Further findings
Technical success
- Technical success
- 92.3% (1,033/1,119)
Follow-up
- Median follow-up
- 43.6 months (Q1-Q3: 35.5-52.7 months)
Original publication
Two-Year Outcomes of the Prospective THRILLER Registry on Popliteal and Infrapopliteal Endovascular Interventions for CLTI. JACC Cardiovasc Interv. Published 26 October 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →