Heart failure & cardiomyopathies
Tyrosine to Threonine Ratio was Related to Heart Failure with Reduced or Mildly Reduced Ejection Fraction
Main finding · Presence of HFResult — go to the resultOdds ratio 3.510 95% CI 2.445–5.040Authors' conclusion
Circulating elevated Tyr/Thr ratio confer an increased risk for the presence of HF and poor prognosis. Tyr/Thr index outweighs FR index in predicting HF occurrence or CV death.
Study context
- Population
- Subjects with chronic HFrEF or HFmrEF and cardiovascular controls without heart failure (HF)77.5% males
- Participants
- 418 subjects
- Comparison
- HFrEF or HFmrEF vs cardiovascular controls without HF
- HFn = 318
- Controln = 100reference
- Outcome
- Association of serum Tyr/Thr ratio with presence of HF
Main finding
Presence of HF
Odds ratio
3.510
95% CI 2.445–5.040
P < 0.001
Tyr/Thr ratio
OR 3.510 (95% CI 2.445–5.040); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
HF endpoint events in HF subjects (higher tyrosine (Tyr)/threonine (Thr) ratio) · mean 11.10 ± 2.80 months
| HR (95% CI) | P value | ||
|---|---|---|---|
| Higher Tyr/Thr ratio269 HF subjects followed up | 2.901 (1.228–6.851) | P = 0.015 | |
| 0.10.31310Hazard ratio (log scale) |
| Outcome | Control |
|---|---|
| Serum Tyr (Control vs HFmrEF vs HFrEF) | 64.43 ± 15.28 μmol/L |
| Serum Thr (Control vs HFmrEF vs HFrEF) | 165.21 ± 40.09 μmol/L |
- Serum Tyr (Control vs HFmrEF vs HFrEF): HFmrEF 71.79 ± 18.74 μmol/L
- Serum Tyr (Control vs HFmrEF vs HFrEF): HFrEF 77.32 ± 25.90 μmol/L
- Serum Tyr (Control vs HFmrEF vs HFrEF): P < 0.001
- Serum Thr (Control vs HFmrEF vs HFrEF): HFmrEF 144.93 ± 44.56 μmol/L
- Serum Thr (Control vs HFmrEF vs HFrEF): HFrEF 135.25 ± 41.25 μmol/L
- Serum Thr (Control vs HFmrEF vs HFrEF): P < 0.001
- AUC, Tyr/Thr ratio vs Fischer's ratio: Tyr/Thr ratio AUC, HF occurrence 0.767 · AUC, cardiovascular (CV) death 0.715
- AUC, Tyr/Thr ratio vs Fischer's ratio: Fischer's ratio (FR) AUC, HF occurrence 0.573 · AUC, CV death 0.550
- AUC, Tyr/Thr ratio vs Fischer's ratio: HF occurrence P < 0.001
- AUC, Tyr/Thr ratio vs Fischer's ratio: CV death P = 0.047
Original publication
Tyrosine to Threonine Ratio was Related to Heart Failure with Reduced or Mildly Reduced Ejection Fraction. ESC Heart Fail. Published 15 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →