Heart failure & cardiomyopathies
U-shaped Catheter Strategy for Percutaneous Endocardial Septal Radiofrequency Ablation in Hypertrophic Obstructive Cardiomyopathy: A Retrospective Comparative Study
Authors' conclusion
The U-shaped catheter strategy for PESA was associated with improved procedural efficiency and greater reduction in LVOT obstruction compared with the conventional catheter approach, while maintaining a favorable safety profile.
Study context
- Population
- Patients with hypertrophic obstructive cardiomyopathy (HOCM) undergoing PESApatients with HOCM undergoing PESA
- Participants
- 27 patients
- Exposure
- Novel U-shaped catheter strategy with the conventional retrograde catheter approach during PESA
- U groupn = 15
- C groupn = 12
- Outcome
- Symptoms, NYHA functional class, and echocardiographic parameters
- Follow-up
- 12-month follow-up
Methodological detailsmatched controls, guided by three-dimensional electroanatomical mapping and intracardiac echocardiography
- Matched controls
- Guided by three-dimensional electroanatomical mapping and intracardiac echocardiography
Main finding
As reported in the abstract
- Both groups demonstrated significant improvements
Observational data: associations, not effects.
Further findings
Catheter-tissue contact force · significantly higher in the U group
P < 0.01
Total radiofrequency delivery time · shorter in the U group
P = 0.01
Resting LVOT gradient · 12 months · significantly lower in the U group
P = 0.03
Safety
- No major complications occurred in either group
- Transient atrioventricular (AV) block and left bundle branch block (LBBB) were observed but required no further intervention
Original publication
U-shaped Catheter Strategy for Percutaneous Endocardial Septal Radiofrequency Ablation in Hypertrophic Obstructive Cardiomyopathy: A Retrospective Comparative Study. Heart Rhythm. Published 25 September 2026. doi:10.
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