Arrhythmias & electrophysiology
Catheter ablation in patients with atrial fibrillation and hypertrophic obstructive cardiomyopathy: a real-world comparative outcomes study
Authors' conclusion
In patients with HOCM and PAF, CA was associated with significantly lower risks of ischemic stroke and all-cause mortality.
Study context
- Population
- Adults (≥18 years) diagnosed with hypertrophic obstructive cardiomyopathy (HOCM) and PAF between 2015 and 2021patients with HOCM and PAF, 1018 (11.8%) underwent catheter ablation (CA), post-PSM 966 matched per group
- Participants
- 8,593 adults
- Comparison
- CA vs. non-CA groups
- CAn = 966
- non-CAn = 966reference
- Outcome
- All-cause mortality and ischemic stroke
- Follow-up
- 3 years
Methodological detailsPropensity score matching (1:1), TriNetX Research Network
- Propensity score matching (1:1)
- TriNetX Research Network
Main finding
As reported in the abstract
CA
- All-cause mortality
- 4.9%
- Ischemic stroke
- 6.4%
non-CA
- All-cause mortality
- 13.7%
- Ischemic stroke
- 9.7%
All-cause mortality
CA4.9%
non-CA13.7%
Ischemic stroke
CA6.4%
non-CA9.7%
CA vs non-CAHazard ratio (95% CI)P value
All-cause mortality
0.35(0.25–0.49)
P < 0.0001Ischemic stroke
0.63(0.46–0.87)
P < 0.01Secondary outcomes
| Outcome | CA | non-CA | HR (95% CI) | P value | |
|---|---|---|---|---|---|
| De novo stroke (patients without prior stroke) | 3.7% | 5.7% | 0.63 (0.40–0.98) | P < 0.05 | |
| CardioversionSecondary outcome | 30.1% | 10.1% | 3.2 (2.5–4.0) | P < 0.0001 | |
| New-onset heart failureSecondary outcome | 69.1% | 72.0% | 1.08 (0.84–1.40) | P = 0.53 | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Catheter ablation in patients with atrial fibrillation and hypertrophic obstructive cardiomyopathy: a real-world comparative outcomes study. Eur Heart J Qual Care Clin Outcomes. Published 26 September 2025. doi:10.
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