U-shaped relationship of HDL and risk of infectious disease: two prospective population-based cohort studies
Authors' conclusion
Low and high HDL cholesterol concentrations found in 21% and 8% of individuals were associated with higher risk of infectious disease in the general population.
Study context
- Population
- General population, Copenhagen General Population Study and Copenhagen City Heart Study, with baseline HDL-C97,166 + 9387 in two cohorts
- Exposure
- Low and high HDL-C vs HDL-C 2.2-2.3 mmol/L
- Outcome
- Any infectious disease requiring hospital admission (Danish health registries)
- Follow-up
- From baseline in 2003-13 or 1991-94 through 2014
Methodological detailstwo cohorts
- Two cohorts
Main finding
As reported in the abstract
Any infection, Copenhagen General Population Study
Each group vs HDL-C 2.2-2.3 mmol/LHazard ratio (95% CI)
HDL-C <0.8 mmol/L
1.75(1.31–2.34)
HDL-C >2.6 mmol/L
1.43(1.16–1.76)
Observational data: associations, not effects.
Further findings
| Outcome | HR (CI) | |
|---|---|---|
| Any infection, Copenhagen City Heart StudyHDL-C <0.8 mmol/L vs HDL-C 2.2-2.3 mmol/L | 2.00 (1.16–3.43) | |
| Any infection, Copenhagen City Heart StudyHDL-C >2.6 mmol/L vs HDL-C 2.2-2.3 mmol/L | 1.13 (0.80–1.60) | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
U-shaped relationship of HDL and risk of infectious disease: two prospective population-based cohort studies. Eur Heart J. Published 8 December 2017. doi:10.
Summarised from the published abstract; every number is checked against it