Ultrathin-strut versus thin-strut stent healing and outcomes in preclinical and clinical subjects
Authors' conclusion
Ultrathin-strut and thin-strut BP-SES demonstrate similar early arterial healing profiles and 30-day and 1-year clinical outcomes.
Study context
- Population
- Rabbits implanted with biodegradable-polymer sirolimus-eluting stents (BP-SES) in the infrarenal aorta; patients undergoing percutaneous coronary intervention (PCI) in the BIOSCIENCE and BIOSTEMI trialsplus 8 rabbits
- Participants
- 504 rabbits
- Comparison
- Ultrathin-strut vs thin-strut BP-SES
- Ultrathin-strutn = 282
- Thin-strutn = 222reference
- Outcome
- Target lesion failure (TLF)
- Follow-up
- 1 year
Methodological detailspreclinical rabbit study, near-infrared fluorescence optical coherence tomography (NIRF-OCT) imaging and histopathology, landmark analysis at 30 days
- Preclinical rabbit study
- NIRF-OCT imaging and histopathology
- Landmark analysis at 30 days
Pooled result
As reported in the abstract
TLF
P = 0.88
Further pooled results
TLF (landmark) · 30 days
P = 0.62
Stent fibrin deposition and uncovered struts (NIRF-OCT, rabbits) · day 7
- Similar stent fibrin deposition
- P = 0.49
- Similar percentage of uncovered stent struts
- P = 0.63
- Histopathological assessments corroborated these findings
- 8 rabbits
Original publication
Ultrathin-strut versus thin-strut stent healing and outcomes in preclinical and clinical subjects. EuroIntervention. Published 20 May 2024. doi:10.
Summarised from the published abstract; every number is checked against it