Heart failure & cardiomyopathies
Uncovering Unrecognized Heart Failure With Preserved Ejection Fraction Among Individuals With Obesity and Dyspnea
Authors' conclusion
Among adults with obesity and dyspnea without known cardiovascular disease, at least a third had clinically unrecognized HFpEF uncovered on invasive cardiopulmonary exercise testing. Clinical, biomarker, resting echocardiography, and diagnostic scores were similar among those with and without HFpEF.
Study context
- Population
- Community research volunteers with obesity and dyspnea without known CVD40 underwent invasive CPET
- Participants
- 78 volunteers
- Exposure
- Heart failure with preserved ejection fraction (HFpEF) vs no HFpEF on invasive CPET
- HFpEFn = 24
- Outcome
- Prevalence of hemodynamic HFpEF
Methodological detailsinvasive cardiopulmonary exercise testing
- Invasive cardiopulmonary exercise testing
Main finding
As reported in the abstract
Prevalence of HFpEF
| Group | Value | Proportion of CPET group |
|---|---|---|
| HFpEF | 31% | 60% |
HFpEF
Value31%
Proportion of CPET group60%
- Diagnosed by rest or exercise PCWP
- 12
- Diagnosed by exercise criteria
- 12
Observational data: associations, not effects.
Further findings
NT-proBNP
Intermediate risk by HFpEF diagnostic scores
H2FPEF intermediate risk
HFA-PEFF intermediate risk
| Outcome | HFpEF | No HFpEF |
|---|---|---|
| Mitral E/e' ratio (resting echocardiography) | 9.1 (SD 3.1) | 8.0 (SD 2.7) |
- NT-proBNP — No differences
- P>0.05
- Mitral E/e' ratio (resting echocardiography) — No differences
- P>0.05
Intermediate risk by HFpEF diagnostic scores
- Distributions of HFpEF diagnostic scores were similar
Original publication
Uncovering Unrecognized Heart Failure With Preserved Ejection Fraction Among Individuals With Obesity and Dyspnea. Circ Heart Fail. Published 14 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →