Heart failure & cardiomyopathies
Understanding the Variability in Red Cell and Plasma Volume Combinations Can Help Guide Management in Heart Failure
An erratum to this article was published (ESC Heart Fail, Jun 2025 ↗)
Authors' conclusion
Findings support the clinical relevance of identifying and accurately interpreting the varying combinations of PV and RBC mass in patients with chronic HF.
Study context
- Population
- Stable NYHA class II–III heart failure (HF) patients
- Participants
- 546 patients
- Outcome
- BV profiles (combinations of PV and RBC mass)
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
- Quantitatively normal blood volume (BV)
- 32% of the cohort
- True normal BV (normal plasma volume (PV) + normal red blood cell (RBC) mass) among normal BV
- ≈1/3
- Normal BV: PV expansion with RBC mass deficit (anaemia)
- 14% of cohort
- Normal BV: PV contraction with RBC mass excess (erythrocythemia)
- 6% of cohort
- Hypervolaemia: PV excess with normal RBC mass
- 21% of cohort; 23% female
- Hypervolaemia: PV excess with erythrocythemia
- 24% of cohort; 26% female
- Hypovolaemia: RBC mass deficit with normal PV
- 6% of cohort; 57% female
- Hypovolaemia: RBC mass deficit with PV contraction
- 5% of cohort; 48% female
Observational data: associations, not effects.
Original publication
Understanding the Variability in Red Cell and Plasma Volume Combinations Can Help Guide Management in Heart Failure. ESC Heart Fail. Published 12 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →