Uptitration of statin therapy in women and men: a population-based cohort study
Main finding · Uptitration of statin intensityResult — go to the resultAdjusted hazard ratio 0.72 95% CI 0.69–0.75Authors' conclusion
Among new statin users, women are less likely to be uptitrated compared to men and to achieve cholesterol target levels.
Study context
- Population
- New statin users with ≥2 recorded statin dispenses, PHARMO Data Network (Netherlands), 2011–202046% women
- Participants
- 68,150 users
- Exposure
- Women vs men
- Outcome
- Time to first uptitration of statin intensity
Main finding
Uptitration of statin intensity
Adjusted hazard ratio
0.72
95% CI 0.69–0.75
By group
Womenvs Men
adjusted HR 0.72 (95% CI 0.69–0.75)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted RR (95% CI) | |
|---|---|---|
| Achieving cholesterol target levels · 6 months after statin initiation | 0.95 (0.93–0.97) | |
| Achieving cholesterol target levels · 18 months after statin initiation | 0.98 (0.97–0.99) | |
| 0.512Adjusted relative risk (log scale) |
Original publication
Uptitration of statin therapy in women and men: a population-based cohort study. Eur Heart J Qual Care Clin Outcomes. Published 17 April 2025. doi:10.
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