Use of Serial Changes in Biomarkers vs. Baseline Levels to Predict Left Ventricular Remodelling After STEMI
Authors' conclusion
Baseline biomarker levels of hsTnT and ST2 were the strongest predictors of LVEF and LVEDV at 12 months after STEMI.
Study context
- Population
- Patients after STEMI treated by PCI, from the ETiCS study
- Participants
- 44 patients
- Comparison
- Baseline biomarker levels vs change in levels (baseline (BL) to 6 months) vs both combined for predicting LV remodelling
- Outcome
- Prediction of dichotomized cardiac MRI values (LVEF, LVEDV, LVESV, infarct size) by CCN1, NT-proBNP, hsTnT and ST2 (AUC)
- Follow-up
- 12 months after STEMI
Methodological detailsserial 3-T cardiac MRI, multiple logistic regression adjusted for age and renal function
- Serial 3-T cardiac MRI
- Multiple logistic regression adjusted for age and renal function
Performance
As reported in the abstract
LVEF prediction (AUC) · 12 months
| Test or model | hsTnT AUC | ST2 AUC |
|---|---|---|
| BL | 0.870 (95% CI: 0.756-0.983) | 0.763 (95% CI: 0.615-0.911) |
| Δ value | 0.870 (95% CI: 0.756-0.983) | 0.809 (95% CI: 0.679-0.939) |
| Combined | 0.891 (0.791-0.992) | 0.778 (0.638-0.918) |
hsTnT AUC
BL0.870 (95% CI: 0.756-0.983)
Δ value0.870 (95% CI: 0.756-0.983)
Combined0.891 (0.791-0.992)
ST2 AUC
BL0.763 (95% CI: 0.615-0.911)
Δ value0.809 (95% CI: 0.679-0.939)
Combined0.778 (0.638-0.918)
- BL vs Δ value: P = 1 — hsTnT
- BL vs Δ value: P = 0.304 — ST2
- Combined vs BL: P = 0.444 — hsTnT; no improvement
- Combined vs BL: P = 0.799 — ST2; no improvement
Further findings
| Outcome | BL |
|---|---|
| Baseline CCN1 and LVEDV at 12 months, infarct size | |
| CCN1 AUC, LVEDV | 0.708 (95% CI: 0.551-0.865) |
| CCN1 AUC, infarct size | 0.703 (95% CI: 0.534-0.872) |
Original publication
Use of Serial Changes in Biomarkers vs. Baseline Levels to Predict Left Ventricular Remodelling After STEMI. ESC Heart Fail. Published 21 October 2022. doi:10.
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