Heart failure & cardiomyopathies
Utility of Left Ventricular Ejection Fraction in Atrial Fibrillation Patients Without Pre-Existing Heart Failure
Authors' conclusion
Lower LVEF was significantly associated with the higher incidence of HF hospitalization in AF patients without pre-existing HF
Study context
- Population
- Atrial fibrillation (AF) patients without pre-existing heart failure (HF) with left ventricular ejection fraction (LVEF) data at enrolment, Fushimi AF Registry, Japanof 3233 without pre-existing HF
- Participants
- 2,459 patients
- Exposure
- Lower LVEF strata vs normal LVEF
- Mildly reduced LVEFn = 114
- Below normal LVEFn = 300
- Normal LVEFn = 2,045reference
- Outcome
- HF hospitalization
- Follow-up
- Median 6.0 years
Methodological detailscommunity-based registry
- Community-based registry
Main finding
As reported in the abstract
Each group vs normal LVEFHazard ratio (95% CI)
Mildly reduced LVEF
2.98(1.99–4.45)
Below normal LVEF
2.01(1.44–2.82)
- Patients hospitalized for HF (overall)
- 255 (10%)
- Annual incidence (overall)
- 1.9% per person-year
Observational data: associations, not effects.
Further findings
HF hospitalization with LVEF < 60%, across major subgroups
- LVEF < 60% significantly associated with higher risk across all major subgroups
- P for interaction; all P > 0.05
Incremental prognostic value beyond natriuretic peptide levels
- LVEF had independent and incremental prognostic value for HF hospitalization in addition to natriuretic peptide levels
Original publication
Utility of Left Ventricular Ejection Fraction in Atrial Fibrillation Patients Without Pre-Existing Heart Failure. ESC Heart Fail. Published 21 August 2023. doi:10.
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