Heart failure & cardiomyopathies
Cardiac Magnetic Resonance Left Ventricular Filling Pressure is Linked to Symptoms, Signs and Prognosis in Heart Failure
Authors' conclusion
Raised CMR-derived LVFP is strongly associated with symptoms and signs of HF. In addition, raised CMR-derived LVFP is independently associated with subsequent HF hospitalization and MACE.
Study context
- Population
- Patients with recently diagnosed heart failure (HF) undergoing same-day cardiovascular magnetic resonance (CMR) and clinical assessment, February 2018–January 2020
- Participants
- 454 patients
- Exposure
- Raised vs normal CMR-derived left ventricular filling pressure (LVFP)
- Raised LVFPn = 135
- Outcome
- MACE:
- CV death
- HF hospitalization
- Non-fatal stroke
- Non-fatal MI
- Follow-up
- Median 2.9 years (IQR 1.5-3.6 years)
Main finding
As reported in the abstract
- Major adverse cardiovascular events (MACE)
- HR 3.1; P < 0.0001
- HF hospitalization
- HR 4.0; P < 0.0001
- MACE, multivariable model
- adjusted HR 3.0; P = 0.0001
- HF hospitalization, multivariable model
- adjusted HR 3.8; P = 0.0001
Observational data: associations, not effects.
Further findings
| Outcome | HR | P value |
|---|---|---|
| Symptoms and signs of HFRaised LVFP vs Normal LVFP · pleural effusions | 3.2 | P = 0.003 |
| Symptoms and signs of HFRaised LVFP vs Normal LVFP · orthopnoea | 2.0 | P = 0.008 |
| Symptoms and signs of HFRaised LVFP vs Normal LVFP · lower limb oedema | 1.7 | P = 0.04 |
| Symptoms and signs of HFRaised LVFP vs Normal LVFP · breathlessness | 1.7 | P = 0.01 |
Original publication
Cardiac Magnetic Resonance Left Ventricular Filling Pressure is Linked to Symptoms, Signs and Prognosis in Heart Failure. ESC Heart Fail. Published 19 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →