Arrhythmias & electrophysiology
Validation of a Demography-Based Adaptive QT Correction Formula Using Pediatric and Adult Datasets Acquired From Humans and Guinea Pigs
Authors' conclusion
The demography-based QTcAd formula showed superior performance across human and guinea pig age groups, which may enhance the efficacy of rate-corrected K.M.M. for cardiovascular disease diagnosis, risk stratification, and drug safety testing in children and adults.
Study context
- Population
- Pediatric patients at Children’s National Hospital, subjects from the Pediatric Heart Network database, and guinea pigs across diverse age groupspediatric patients at Children’s National Hospital 1,819 · subjects from the Pediatric Heart Network database 2,400 · in vivo guinea pig ECG recordings N=55 · ex vivo guinea pig ECG recordings N=66
- Comparison
- QTcAd formula compared to other standard formulae
- Outcome
- QTc-HR linear regression fit (R ² and slope), 20-year-old human group
Methodological detailsretrospective ECG data, in vivo and ex vivo guinea pig ECG recordings, Langendorff-perfused guinea pig hearts
- Retrospective ECG data
- In vivo and ex vivo guinea pig ECG recordings
- Langendorff-perfused guinea pig hearts
Performance
As reported in the abstract
| Test or model | R ² | Slope |
|---|---|---|
| QTcAd | 5.1×10 −10 | −3.5×10 −5 |
| Bazett formula | 0.21 | 0.91 |
R ²
QTcAd5.1×10 −10
Bazett formula0.21
Slope
QTcAd−3.5×10 −5
Bazett formula0.91
Further findings
| Outcome | QTcAd | Benatar QTc formula |
|---|---|---|
| QTc accuracy, 1-week human | 263.8±7.3 ms | 422.5±7.3 ms |
| Optically measured pseudo-QT interval approximation | 180.6±17.0 ms | — not stated in the abstract |
— not stated in the abstract
- QT correction (QTc) accuracy, 1-week human: QT 263.8±14.8 ms
- QTc accuracy, 1-week human: QTcAd P =0.62
- QTc accuracy, 1-week human: Benatar QTc P <0.0001 (overcorrected QTc)
- Optically measured pseudo-QT interval approximation: Optical pseudo-QT 143±22.5 ms
- Optically measured pseudo-QT interval approximation: n=44
Optically measured pseudo-QT interval approximation
- Better approximated by QTcAd compared with all other formulae
QTcAd vs individual-specific QTc formulae
- QTcAd formula was not inferior to individual-specific QTc formulae
Original publication
Validation of a Demography-Based Adaptive QT Correction Formula Using Pediatric and Adult Datasets Acquired From Humans and Guinea Pigs. Circ Arrhythm Electrophysiol. Published 3 February 2025. doi:10.
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