Valvular & structural heart disease
Valvular Heart Disease-Related Mortality Between Middle- and High-Income Countries During 2000 to 2019
Authors' conclusion
Our study identified a rising burden of VHD-related mortality worldwide. The distribution and trends of VHD mortality differed between middle- and high-income countries.
Study context
- Population
- Countries in the WHO Mortality Database, Valvular Heart Disease (VHD) mortality 2000–2019
- Participants
- 93 countries
- Exposure
- Middle-income vs high-income countries
- Middle-incomen = 42
- High-incomen = 51reference
- Outcome
- Age-standardized VHD-related mortality rate trend (per 100,000 persons)
- Follow-up
- 2000 to 2019
Methodological detailsWHO Mortality Database, joinpoint regression
- WHO Mortality Database
- Joinpoint regression
Main finding
As reported in the abstract
Age-standardized VHD-related mortality rate trend
Middle-income
0.0%/year
High-income
−0.6%/year
Observational data: associations, not effects.
Further findings
Crude VHD mortality rate trend · 2000–2019
- Increasing trend in both middle- and high-income countries
Age-standardized mortality trend by VHD subgroup, middle-income countries · 2000–2019
- RVD
- −2.7%/year
- IE
- 0.8%/year
- AS
- 2.0%/year
- MR
- 2.2%/year
IE mortality rate trend, age ≤39 years, high-income countries · after 2009
- Rapid increase in IE mortality rate in age ≤39 years after 2009 (high-income)
- 7.0%/year
AS and MR mortality rate trends, high-income countries
- Decreasing AS mortality rate after 2015
- Increasing MR mortality rate after 2013, particularly in age ≥80 years
Original publication
Valvular Heart Disease-Related Mortality Between Middle- and High-Income Countries During 2000 to 2019. JACC Adv. Published 28 August 2024. doi:10.
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