Valvular & structural heart diseaseCohort study
Atrial Functional Mitral Regurgitation Subtypes Undergoing Transcatheter Edge-to-Edge Repair
- Retrospective cohort study
- consecutive patients
Authors' conclusion
AFMR-AH shows worse procedural and clinical outcomes following M-TEER than AFMR-IAD.
Study context
- Population
- Patients with atrial functional mitral regurgitation undergoing mitral valve transcatheter edge-to-edge repair (M-TEER)of 1,047 M-TEER patients
- Participants
- 128 patients
- Exposure
- AFMR-AH vs AFMR-IAD undergoing M-TEER
- AFMR-AHn = 53
- AFMR-IADn = 75reference
Main finding
As reported in the abstract
Procedural failure (30 days) and all-cause mortality (1 year)
AFMR-AH
43.4%
Procedural failure at 30 days · Kaplan-Meier estimated 1-year survival 77%
AFMR-IAD
24.0%
Procedural failure at 30 days · Kaplan-Meier estimated 1-year survival 92%
AFMR-AH vs AFMR-IADEstimate (95% CI)P value
procedural failure at 30 days; 43.4% vs 24.0%, P = 0.023
OR 1.17(1.00–1.38)
P = 0.045all-cause mortality at 1 year; survival 77% vs 92%, P = 0.017
HR 2.54(1.09–5.91)
P = 0.031Observational data: associations, not effects.
Further findings
Technical success
MR ≤II · 30 days and 1 year
30 days
1 year
- Technical success: P = 0.009
- MR ≤II: 30 days P = 0.009
- MR ≤II: 1 year P = 0.038
Baseline echocardiography
- AFMR-AH: greater LA and LV volumes, greater mitral annulus, shorter and steeper posterior leaflet, more pronounced MR
- all P < 0.05
Safety
| Outcome | AFMR-IAD | AFMR-AH |
|---|---|---|
| Device detachment at discharge | Not reported in the abstract | 10.0% |
Device detachment at discharge
- Observed exclusively in AFMR-AH
Original publication
Atrial Functional Mitral Regurgitation Subtypes Undergoing Transcatheter Edge-to-Edge Repair. JACC Cardiovasc Imaging. Published 28 August 2024. doi:10.1016/j.jcmg.2024.06.019
Summarised from the published abstract; every number is checked against it