Cardio-oncology & otherMeta-analysis
Variants at the Interleukin 1 Gene Locus and Pericarditis
- Genome-wide association study meta-analysis
- 5 countries
- multiomic (cis-eQTL, pQTL, ASM-QTL)
Authors' conclusion
This study found an association between pericarditis and 2 independent sequence variants at the interleukin 1 gene locus.
Study context
- Population
- Individuals with pericarditis in Iceland, Denmark, UK, US and Finland cohortswith pericarditis
- Participants
- 4,894 individuals
- Comparison
- Variants at the interleukin 1 locus and pericarditis
- Outcome
- Pericarditis
Pooled result
As reported in the abstract
Estimate (95% CI)P value
rs12992780 (T)lead variant, downstream of IL1B; EAF 31%-40%
OR 0.83(0.79–0.87)
P = 6.67 × 10-16rs7575402 (A or T)secondary variant; EAF 45%-55%
adjusted OR 0.89(0.85–0.93)
adjusted P = 9.6 × 10-8Further pooled results
rs12992780 by pericarditis subtype
- OR, recurrent pericarditis
- 0.76
- OR, acute pericarditis
- 0.86
- P for heterogeneity = .03
rs7575402 and CpG methylation
- Associated with CpG methylation overlapping binding sites of 4 transcription factors regulating interleukin 1 production: PU.1 (SPI1), STAT1, STAT3, C/EBPβ (CEBPB)
Original publication
Variants at the Interleukin 1 Gene Locus and Pericarditis. JAMA Cardiol. Published 1 February 2024. doi:10.1001/jamacardio.2023.4820
Summarised from the published abstract; every number is checked against it