Variation in Health Status With Invasive vs Conservative Management of Chronic Coronary Disease
Authors' conclusion
In the management of chronic coronary disease, individual patient characteristics are associated with 1-year health status, with younger age and poorer angina-related health status showing greater benefit from invasive management.
Study context
- Population
- Patients with chronic coronary disease in the ISCHEMIA trial
- Participants
- 4,617 patients
- Comparison
- Invasive vs conservative strategy
- Primary endpoint
- Disease-specific health status: SAQ Summary Score and Angina Frequency, Physical Limitations and Quality of Life domains (0-100, higher = better)
- Follow-up
- 1 year
Methodological details320 sites in 37 countries, Parsimonious prediction models developed for 1-year Seattle Angina Questionnaire (SAQ) domains with invasive or conservative strategies to support shared decision-making
- 320 sites in 37 countries
- Parsimonious prediction models developed for 1-year SAQ domains with invasive or conservative strategies to support shared decision-making
Primary result
As reported in the abstract
Treatment interactions for 1-year health status (SAQ SS)
- Lower baseline SAQ SS associated with better 1-year health status with invasive strategy
- P interaction = 0.009
- Younger age associated with better 1-year health status with invasive strategy
- P interaction = 0.004
Further findings
SAQ SS overall · baseline and 1 year
- Mean SAQ SS at baseline
- 74.1 ± 18.9
- Mean SAQ SS at 1 year
- 85.7 ± 15.6
Original publication
Variation in Health Status With Invasive vs Conservative Management of Chronic Coronary Disease. J Am Coll Cardiol. Published 16 April 2024. doi:10.
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