Vascular Assessment in Adult Survivors of Childhood Cancer: A St. Jude Lifetime Cohort Study Report
Authors' conclusion
CCSs have evidence of early vascular dysfunction, suggestive of premature atherogenesis.
Study context
- Population
- Adult survivors of childhood cancer and sex- and age-matched controls
- Participants
- 200 vs 192
- Exposure
- Differences between CCSs and sex- and age-matched controls
- CCSsn = 200
- Controlsn = 192
- Outcome
- plasminogen activator inhibitor-1
Methodological detailssex- and age-matched controls, multivariable general linear regression models, adjusted for body mass index, race and ethnicity, smoking, and physical activity
- Sex- and age-matched controls
- Multivariable general linear regression models, adjusted for body mass index, race and ethnicity, smoking, and physical activity
Main finding
As reported in the abstract
P = 0.007
Observational data: associations, not effects.
Further findings
Endothelial surface expression of vascular cell adhesion molecule-1 · significantly elevated in CCSs
P < 0.001
Endothelial surface expression of P-selectin · significantly elevated in CCSs
P < 0.001
AIx · significantly elevated in CCSs
P < 0.001
Large artery elasticity · reduced in CCSs
P = 0.013
Small artery elasticity · reduced in CCSs
P < 0.001
Pulse wave velocity · significantly elevated in CCSs
P < 0.001
| Outcome | CCSs | Controls |
|---|---|---|
| Participant characteristics | ||
| Median time from diagnosis | 26.3 years [range: 11.2-47.9 years] | — not stated in the abstract |
| Current age | 33.5 years [range: 19.3-61.6 years] | — not stated in the abstract |
| Age | — not stated in the abstract | 33.3 years [range: 18.3-60.3 years] |
— not stated in the abstract
- Augmentation index (AIx) by chest radiation exposure among survivors (subgroup): survivors exposed to chest radiation 15.4%
- AIx by chest radiation exposure among survivors (subgroup): survivors not exposed 11.2%
Original publication
Vascular Assessment in Adult Survivors of Childhood Cancer: A St. Jude Lifetime Cohort Study Report. JACC Adv. Published 29 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →