Arrhythmias & electrophysiology
Vascular cell adhesion molecule 1: a marker for atrial fibrillation and heart failure risk
Authors' conclusion
Higher sVCAM-1 levels were associated with AF and HF and lower LAEF. Integration of an AF PRS with sVCAM-1 levels identified a dose-response-like relationship with risk of AF.
Study context
- Population
- UK Biobank participants included 2006–2010, follow-up to 202354.6% women
- Participants
- 48,495 participants
- Exposure
- Higher vs lower sVCAM-1 levels
- Outcome
- Incident AF and HF
Methodological detailsUK Biobank
- UK Biobank
Main finding
As reported in the abstract
Atrial fibrillation (AF) per SD increase in sVCAM-1, HR
1.72 (1.54-1.91) (95% CI)
Heart failure (HF) per SD increase in sVCAM-1, HR
2.04 (1.78-2.34) (95% CI)
Diagnosed with AF during follow-up
3484
Diagnosed with clinical HF during follow-up
1937
Observational data: associations, not effects.
Further findings
10-year cumulative incidence, highest sVCAM-1 tertile
- AF, %
- 6.44% (6.05-6.82) (95% CI)
- HF, %
- 3.01% (2.74-3.29) (95% CI)
AF risk stratified by tertiles of AF polygenic risk score (PRS) and sVCAM-1
- Dose-response-like relationship emerged
LAEF with higher sVCAM-1 (CMR sub-cohort, n = 933)
- Reduced LAEF, β
- −2.51 (−4.33 to −0.70) (95% CI)
Original publication
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