Arrhythmias & electrophysiology
Ventricular conduction is a marker for arrhythmic risk in SCN5A- E1784K overlap sodium channel disease
Authors' conclusion
Ventricular myocardial conduction appears likely to play a role in the risk of arrhythmic events in patients with SCN5A-E1784K.
Study context
- Population
- Subjects with SCN5A-E1784K (LQTS/Brugada syndromes (BrS) overlap sodium channel disease) from Europe, US and Japan
- Participants
- 231 subjects
- Outcome
- Lethal events (sudden death, non-fatal cardiac arrest, documented sustained VT or VF) and cardiac events (arrhythmic syncope plus any lethal event)
Methodological detailsmulticentre, observational
- Multicentre
- Observational
Main finding
As reported in the abstract
Lethal event
14
6%
Cardiac event
45
19%
Observational data: associations, not effects.
Original publication
Ventricular conduction is a marker for arrhythmic risk in SCN5A- E1784K overlap sodium channel disease. Europace. Published 11 May 2026. doi:10.
Summarised from the published abstract; every number is checked against it