Acute cardiac care & resuscitation
Ventricular Fibrillation/Ventricular Tachycardia Within 72 h of Veno-arterial Extracorporeal Membrane Oxygenation (VA-ECMO): Incidence, Outcomes, Risk Factors, and Management
Authors' conclusion
An iHR > 120 b.p.m. and hyperlactataemia were independent risk factors for the occurrence of VF/VT within 72 h of VA-ECMO initiation. The occurrence of VF/VT does not affect, nor does defibrillation in these patients improve the overall patient prognosis.
Study context
- Population
- Patients undergoing VA-ECMO (refractory cardiogenic shock or cardiac arrest), First Affiliated Hospital of Nanjing Medical University, January 2017–March 2022
- Participants
- 126 patients
- Exposure
- VF/VT vs no VF/VT within 72 h of VA-ECMO initiation
- VF/VTn = 35
- Outcome
- Incidence of and independent risk factors for VF/VT; effect of VF/VT on 28-day survival
- Follow-up
- Within 72 h of VA-ECMO initiation
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Odds ratio (95% CI)P value
iHR > 120 b.p.m.
6.117(1.672–22.376)
P = 0.006Hyperlactataemia
1.125(1.016–1.246)
P = 0.023- Incidence of VF/VT within 72 h of VA-ECMO initiation
- 27.78% (35/126)
Observational data: associations, not effects.
Secondary outcomes
VF/VT incidence by indication: cardiac arrest vs refractory cardiogenic shock
- Cardiac arrest vs refractory cardiogenic shock
- 80% vs. 20%; P = 0.022
28-day survival (overall cohort)
- 28-day survival rate
- 57.14% (72/126)
Other secondary endpoints (incl. ICU length of stay)
- VF/VT did not affect other secondary endpoints
Defibrillation in VF/VT (subgroup)
- Defibrillation did not alter overall prognosis
Original publication
Ventricular Fibrillation/Ventricular Tachycardia Within 72 h of VA-ECMO: Incidence, Outcomes, Risk Factors, and Management. ESC Heart Fail. Published 13 December 2023. doi:10.
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