Arrhythmias & electrophysiology
Ventricular Tachycardia Ablation in Patients With Desmoplakin Cardiomyopathy
Authors' conclusion
Patients with DSP cardiomyopathy often have biventricular involvement, and ablation procedures often require ablation in both ventricles and the epicardium. Recurrences are not uncommon, and the pathologic substrate can be located in close proximity to epicardial coronary arteries, limiting the success rate of ablations.
Study context
- Population
- Patients with desmoplakin (DSP) pathogenic variants (DSP cardiomyopathy) undergoing ventricular tachycardia (VT) ablation11 previous failed ablations
- Participants
- 20 patients
- Outcome
- Acute and long-term VT ablation outcomes
- Follow-up
- Median 18 months [Q1-Q3: 5-60 months]
Methodological details6 centres in 3 countries
- 6 centres in 3 countries
Main finding
As reported in the abstract
median follow-up 18 months [Q1-Q3: 5-60 months]
- Epicardial procedures
- 16 of the 20 patients
- VT target sites: Right ventricular (RV) endocardium
- n = 11
- VT target sites: RV epicardium
- n = 4
- VT target sites: Left ventricular (LV) endocardium
- n = 2
- VT target sites: LV epicardium
- n = 7
- VT target sites close to coronary arteries, limiting ablation
- 3 patients
- VT recurrence during follow-up
- 11 patients
- Repeated ablations
- 9 patients
- Free of VT recurrence allowing for multiple procedures
- 19 of the 20 patients
Observational data: associations, not effects.
Further findings
Baseline characteristics
- Men
- 13
- Median age
- 43 years [Q1-Q3: 41.5-53.0 years]
- LVEF
- 43.0% [Q1-Q3: 41.5%-53.0%]
- ICD therapy
- 19 patients
- All patients had symptomatic VTs
Original publication
Ventricular Tachycardia Ablation in Patients With Desmoplakin Cardiomyopathy. JACC Clin Electrophysiol. Published 10 January 2024. doi:10.
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