Arrhythmias & electrophysiology
Ventricular Tachycardia Predicts All-Cause Mortality and Nonsudden Cardiac Death in Nonischemic Cardiomyopathy
Main finding · All-cause mortality or heart transplantationResult — go to the resultAdjusted hazard ratio 4.27 95% CI 2.60–7.03Authors' conclusion
Patients with NICM experiencing VT are at an increased risk for mortality and NSCVD, suggesting that VT can be a marker for a more severe cardiomyopathy with important clinical implications.
Study context
- Population
- Patients with nonischemic cardiomyopathy (NICM) and ICDs enrolled in DANISH (ICD for primary prevention of sudden death) and dilated cardiomyopathy-VT (ventricular tachycardia (VT) ablation)median age 64 years, 23.3% females, median left-ventricular ejection fraction of 36%
- Participants
- 828 patients
- Exposure
- Patients with vs without VT
- Outcome
- All-cause mortality or heart transplantation
- Follow-up
- Median 3.9 years
Methodological detailsmulticentre, multivariable analysis, propensity-matched subgroup
- Multicentre
- Multivariable analysis
- Propensity-matched subgroup
Main finding
As reported in the abstract
Adjusted hazard ratio
4.27
95% CI 2.60–7.03
VTvs without VT
adjusted HR 4.27 (95% CI 2.60–7.03)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Adjusted HR (95% CI) | |
|---|---|---|
| Nonsudden cardiovascular death (NSCVD) (secondary endpoint)7-fold increase in NSCVD | 7.28 (3.80–13.97) | |
| 0.050.21520Adjusted hazard ratio (log scale) |
Deaths during follow-up · median follow-up of 3.9 years
- Deaths
- 148
- Deaths due to nonsudden cardiovascular death (NSCVD)
- 78 (53%)
Subgroups
- The findings were consistent across all subgroups
Original publication
Ventricular Tachycardia Predicts All-Cause Mortality and Nonsudden Cardiac Death in Nonischemic Cardiomyopathy. JACC Adv. Published 13 August 2025. doi:10.
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