Worsening of Chronic Heart Failure: Definition, Epidemiology, Management and Prevention. A Clinical Consensus Statement by the Heart Failure Association of the European Society of Cardiology

Worsening heart failure (HF) episodes usually require diuretic therapy: IV, escalated oral doses or combinations of diuretic classes

Additional treatments, including initiation of guideline-recommended medical therapy (GRMT), may have a major role

Prevention of first and recurring episodes of worsening HF is essential and may be achieved through early and rapid administration of GRMT