Prevention & lipidsCohort study
Xylitol is prothrombotic and associated with cardiovascular risk
- Prospective cohort study with mechanistic and intervention studies
- discovery and validation cohorts
- untargeted metabolomics
- LC-MS/MS
Authors' conclusion
Xylitol is associated with incident MACE risk. Moreover, xylitol both enhanced platelet reactivity and thrombosis potential in vivo.
Study context
- Population
- Stable subjects undergoing elective diagnostic cardiac evaluations; healthy volunteers in the intervention studydiscovery n = 1157
- Exposure
- Third vs first tertile of plasma xylitol
- Outcome
- Incident MACE
- Follow-up
- 3 years
Main finding
Incident MACE (validation cohort)
Adjusted hazard ratio
1.57
95% CI 1.12–2.21
P < 0.01
Third tertile vs First tertile
adjusted HR 1.57 (95% CI 1.12–2.21); P < 0.01
As reported in the abstract
Observational data: associations, not effects.
Further findings
Incident major adverse cardiovascular event (MACE) (discovery cohort, untargeted metabolomics) · 3 years
- Circulating polyol tentatively assigned as xylitol associated with incident MACE risk
Platelet reactivity and thrombosis (mechanistic studies)
- Xylitol enhanced multiple indices of platelet reactivity and in vivo thrombosis formation at levels observed in fasting plasma
Platelet function after xylitol-sweetened drink (healthy volunteers, n = 10)
- Markedly raised plasma levels and enhanced multiple functional measures of platelet responsiveness in all subjects
Original publication
Xylitol is prothrombotic and associated with cardiovascular risk. Eur Heart J. Published 6 June 2024. doi:10.1093/eurheartj/ehae244
Summarised from the published abstract; every number is checked against it