Arrhythmias & electrophysiology
Zero-contrast left atrial appendage closure, a feasible alternative for patients with a high risk of contrast-induced nephropathy: Systematic literature review and meta-analysis
Pooled result · Feasibility: successful implantation, recaptures, fluoroscopy timeResult — go to the resultMean difference −4.03 CI −7.72 to −0.34Authors' conclusion
Zero-contrast LAAC is a feasible alternative. The success and complication rates are consistent with those of conventional LAAC. Aside from the inherent benefit of zero-contrast exposure, this technique allows a reduction in fluoroscopy time.
Study context
- Population
- Patients with nonvalvular AF undergoing left atrial appendage closure
- Participants
- 367 patients5 studies
- Comparison
- Zero-contrast left atrial appendage closure (LAAC) vs conventional LAAC
- Outcome
- Feasibility and safety of zero-contrast LAAC
Methodological detailsrandom-effects model
- Random-effects model
Pooled result
As reported in the abstract
Feasibility: successful implantation, recaptures, fluoroscopy time
Mean difference
−4.03
CI −7.72 to −0.34
P = 0.03
By group
Zero-contrast
100%
Zero-contrastvs Conventional
mean difference −4.03 (CI −7.72 to −0.34); P = 0.03
- Mean number of recaptures: no significant difference between groups (MD −0.15; CI −0.67 to 0.37; I2 = 0%)
- P = 0.58
Safety
Procedure-related complications, peridevice leak, device-associated thrombus
- Not significantly different between groups
Original publication
Zero-contrast left atrial appendage closure, a feasible alternative for patients with a high risk of contrast-induced nephropathy: Systematic literature review and meta-analysis. Heart Rhythm. Published 13 May 2024. doi:10.
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