1- or 3-Month DAPT in Patients With HBR With or Without Oral Anticoagulant Therapy After Percutaneous Coronary Intervention (PCI)
Primary result · Death or MI, OAC patientsResult — go to the resultAdjusted hazard ratio 0.74 95% CI 0.49–1.11Authors' conclusion
Between 1 and 12 months after PCI, 1-month compared with 3-month DAPT was associated with similar rates of all-cause death or MI and a reduced rate of BARC types 2 to 5 bleeding, irrespective of OAC treatment.
Study context
- Population
- Patients with high bleeding risk after successful PCI with a cobalt-chromium everolimus-eluting stent, free from ischemic events and adherent to treatment, with or without oral anticoagulation (OAC)1,462 (43%) on OAC
- Participants
- 3,364 patients
- Comparison
- 1-month vs 3-month DAPT, in patients with and without OAC
- Primary endpoint
- All-cause death or any myocardial infarction (MI)
- Follow-up
- 1 to 12 months after index PCI
Methodological detailspropensity score stratification
- Propensity score stratification
Primary result
Death or MI, OAC patients
Adjusted hazard ratio
0.74
95% CI 0.49–1.11
P = 0.139
By group
1-month DAPTvs 3-month DAPT
adjusted HR 0.74 (95% CI 0.49–1.11); P = 0.139
As reported in the abstract
- Effects consistent in patients with and without OAC
- P for interaction = NS
Safety
| Outcome | Adjusted HR (95% CI) | P value | |
|---|---|---|---|
| BARC types 2 to 5 bleeding, OAC patients (key secondary endpoint) | 0.71 (0.51–0.99) | P = 0.046 | |
| 0.512Adjusted hazard ratio (log scale) |
Original publication
1- or 3-Month DAPT in Patients With HBR With or Without Oral Anticoagulant Therapy After PCI. JACC Cardiovasc Interv. Published 4 October 2023. doi:10.
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