10-Year Excess Mortality After First-Time Non–ST-Segment Elevation Myocardial Infarction: The Western Denmark Heart Registry
Main finding · Mortality (excess mortality), 0 to 30 daysResult — go to the resultHazard ratio 8.90 95% CI 7.40–10.68Authors' conclusion
Among first-time NSTEMI patients treated with PCI, 90-day survivors had a substantially higher 10-year excess mortality than the matched general population. This excess mortality was primarily driven by NSTEMI patients with a high baseline comorbidity burden.
Study context
- Population
- First-time NSTEMI patients treated with percutaneous coronary intervention (PCI) identified in the Western Denmark Heart Registry from 2010 to 2022first-time NSTEMI patients treated with PCI, plus 53,739 matched individuals
- Participants
- 10,748 patients
- Exposure
- Mortality was compared with a general population cohort matched by age, sex, and calendar year
- NSTEMI patientsn = 10,748
- General populationn = 53,739reference
- Outcome
- Mortality (excess mortality), 0 to 30 days
- Follow-up
- 0 to 30 days
Methodological detailsmatched by age, sex, and calendar year, landmark periods
- Matched by age, sex, and calendar year
- Landmark periods
Main finding
As reported in the abstract
Hazard ratio
8.90
95% CI 7.40–10.68
NSTEMI patientsvs general population
HR 8.90 (95% CI 7.40–10.68)
- Excess mortality
- 1.9% (95% CI: 1.6-2.2)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Mortality (excess mortality), 31 to 90 daysHigher mortality in NSTEMI patients | 2.54 (2.06–3.15) | |
| Mortality (excess mortality), 91 days to 10 yearsHigher mortality in NSTEMI patients | 1.26 (1.21–1.32) | |
| 0.20.5125Hazard ratio (log scale) |
- Mortality (excess mortality), 31 to 90 days — excess mortality
- 0.5% (95% CI: 0.3-0.7)
- Mortality (excess mortality), 91 days to 10 years — excess mortality
- 6.1% (95% CI: 4.8-7.5)
Follow-up
- Median follow-up
- 6.0 (Q1-Q3: 3.4-9.2) years
Excess mortality in patients with a high comorbidity burden (subgroup)
- Excess mortality, patients with a high comorbidity burden
- 22.0%; 95% CI: 19.1-24.9
- Excess risk almost exclusively confined to patients with a high comorbidity burden
Original publication
10-Year Excess Mortality After First-Time Non–ST-Segment Elevation Myocardial Infarction: The Western Denmark Heart Registry. JACC Adv. Published 23 March 2026. doi:10.
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