Coronary disease & ACSMeta-analysis
Prognostic Value of Microvascular Resistance Reserve in Coronary Artery Disease
- Systematic review and meta-analysis of prospective studies
- random-effects model
Authors' conclusion
MRR is a robust, independent predictor of cardiovascular outcomes of both acute and chronic CAD.
Study context
- Population
- Patients with coronary artery disease (CAD) across various presentations
- Participants
- 3,186 patients · 5 studies
- Comparison
- Higher vs lower microvascular resistance reserve (MRR)
- Outcome
- MACE in relation to MRR
Pooled result
As reported in the abstract
MACE
Higher MRR associated with lower risk of adverse events, HR per unit increase
0.75 (95% CI 0.64-0.88; I² = 80.9%)
Low MRR (dichotomized) vs high MRR, HR for MACE
2.39 (95% CI 1.66-3.43)
Further pooled results
MACE by presentation (subgroup)
- STEMI, HR
- 0.46
- Stable CAD, HR
- 0.86
- P for interaction < 0.0001
MRR threshold analysis
- MRR ≥ 3 optimal for sensitivity and rule-out performance; sensitivity
- 58.9%
- Lower thresholds improved specificity
Original publication
Prognostic Value of Microvascular Resistance Reserve in Coronary Artery Disease. JACC Cardiovasc Interv. Published 23 March 2026. doi:10.1016/j.jcin.2025.12.022
Summarised from the published abstract; every number is checked against it