2026 AHA/ACC/ACCP/ACEP/CHEST/SCAI/SHM/SIR/SVM/SVN Guideline for the Evaluation and Management of Acute Pulmonary Embolism in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

Creager, MA; Barnes, GD; Giri, J; Mukherjee, D; Jones, WS; Burnett, AE; Carman, T; Casanegra, AI; Castellucci, LA; Clark, SM; Cushman, M; de Wit, K; Eaves, JM; Fang, MC; Goldberg, JB; Henkin, S; Johnston-Cox, H; Kadavath, S; Kadian-Dodov, D; Keeling, WB; Klein, AJP; Li, J; McDaniel, MC; Moores, LK; Piazza, G; Prenger, KS; Pugliese, SC; Ranade, M; Rosovsky, RP; Russo, F; Secemsky, EA; Sista, AK; Tefera, L; Weinberg, I; Westafer, LM; Young, MN

doi:10.1016/j.jacc.2025.11.005

Pulmonary vascular disease & thromboembolism

2026 AHA/ACC/ACCP/ACEP/CHEST/SCAI/SHM/SIR/SVM/SVN Guideline for the Evaluation and Management of Acute Pulmonary Embolism in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

J Am Coll CardiolPublished 19 Feb 2026Clinical practice guideline

An erratum to this article was published (J Am Coll Cardiol, 11 Aug 2026 ↗)

Read the original article ↗PubMed

Cite

Methodological detailsLiterature search February 2024 to October 2024 (MEDLINE, EMBASE, Cochrane Library, AHRQ and other databases); key studies until April 2025 added

Literature search February 2024 to October 2024 (MEDLINE, EMBASE, Cochrane Library, AHRQ and other databases); key studies until April 2025 added

Recommendations

As issued by the authors

Introduces the AHA/ACC Acute Pulmonary Embolism Clinical Categories for severity classification, prognosis assessment and therapeutic decision-making

Reference

Issued by: AHA/ACC/ACCP/ACEP/CHEST/SCAI/SHM/SIR/SVM/SVN
Document: De novo clinical practice guideline
Scope: Evaluation, management and follow-up of adults with acute PE, from symptom onset through clinical follow-up: risk assessment, diagnosis, adjunctive CV testing, pharmacological and advanced interventional therapies, in-hospital support, acute and early post-acute phases

Authors: Creager MA, Barnes GD, Giri J, Mukherjee D, Jones WS, Burnett AE, et al.
All 36 authors
Creager MA, Barnes GD, Giri J, Mukherjee D, Jones WS, Burnett AE, Carman T, Casanegra AI, Castellucci LA, Clark SM, Cushman M, de Wit K, Eaves JM, Fang MC, Goldberg JB, Henkin S, Johnston-Cox H, Kadavath S, Kadian-Dodov D, Keeling WB, Klein AJP, Li J, McDaniel MC, Moores LK, Piazza G, Prenger KS, Pugliese SC, Ranade M, Rosovsky RP, Russo F, Secemsky EA, Sista AK, Tefera L, Weinberg I, Westafer LM, Young MN
Journal: JACC
Published: 19 Feb 2026
DOI: 10.1016/j.jacc.2025.11.005
PubMed: 41712898

Topic: Pulmonary vascular disease & thromboembolism

Original publication

2026 AHA/ACC/ACCP/ACEP/CHEST/SCAI/SHM/SIR/SVM/SVN Guideline for the Evaluation and Management of Acute Pulmonary Embolism in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. Published 19 February 2026. doi:10.1016/j.jacc.2025.11.005

Read the original article ↗

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