Heart failure & cardiomyopathies
A 20-year population study of peripartum cardiomyopathy
Authors' conclusion
PPCM affected 1 in 4950 women around the time of pregnancy. The condition is associated with considerable morbidity and mortality for the mother and child.
Study context
- Population
- Validated cases of peripartum cardiomyopathy in Scotland, 1998–2017women with PPCM
- Participants
- 225 cases
- Exposure
- Women with PPCM vs matched controls
- PPCMn = 225
- Outcome
- Incidence of PPCM
Methodological detailsobservational, population-level, matched controls (1:10)
- Observational
- Population-level
- Matched controls (1:10)
Main finding
As reported in the abstract
PPCM
1 in 4950 deliveries
Observational data: associations, not effects.
Further findings
| Outcome | PPCM |
|---|---|
| All-cause death and any-cause rehospitalization (≥1) · median 8.3 years | |
| Died | 8% |
| Rehospitalized for any cause at least once | 75% |
- All-cause death and any-cause rehospitalization (≥1) — Mortality rate in PPCM vs controls
- ∼12-times
- All-cause death and any-cause rehospitalization (≥1) — Rehospitalization rate in PPCM vs controls
- ∼3-times
Risk factors for PPCM
- Obesity, gestational hypertensive disorders and multi-gestation associated with PPCM
Composite of all-cause death, mechanical circulatory support or cardiac transplantation
- Composite occurred
- 14%
LV recovery · median 9.7 years (echocardiographic outcomes)
- LV recovery
- 76%
- Decline in LV systolic function after initial recovery (of those recovered)
- 13%
Children born to women with PPCM vs children of controls · median 8.8 years
- Mortality rate vs children of controls
- ∼5-times
- Incidence of CVD vs children of controls
- ∼3-times greater
Original publication
A 20-year population study of peripartum cardiomyopathy. Eur Heart J. Published 7 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →