Heart failure & cardiomyopathies
Impact of Adherence to Guideline-Directed Therapy on Risk of Death in Heart Failure (HF) Patients Across an Ejection Fraction Spectrum
Authors' conclusion
Good adherence to GDMT works best in patients with LVEF < 50%, whereas moderate adherence to GDMT varies in efficacy depending on the components of the drug combinations.
Study context
- Population
- HF patients with no missing LVEF, Swedish Heart Failure Registry; adherence score good, moderate or poor by triple, double or single use of ACEi/ARB, beta-blockers and MRAmean age 73.9 ± 12.1 years
- Participants
- 64,610 patients
- Exposure
- Good vs moderate vs poor adherence to guideline-directed medical therapy (GDMT), across LVEF categories
- Outcome
- Time to all-cause mortality
Methodological detailsSwedish Heart Failure Registry
- Swedish Heart Failure Registry
Main finding
As reported in the abstract
All-cause mortality
LVEF <30% vs LVEF ≥50%Hazard ratio (95% CI)P value
With good GDMT adherence: similar mortality
0.97(0.86–1.10)
P = 0.664- LVEF <30% had the highest mortality, almost 20% higher than LVEF ≥50%
- HR 0.80 (95% CI 0.71–0.90); P < 0.001
Observational data: associations, not effects.
Further findings
- Good adherence
- 20%
- Moderate or poor GDMT adherence was alarmingly high
Original publication
Impact of Adherence to Guideline-Directed Therapy on Risk of Death in HF Patients Across an Ejection Fraction Spectrum. ESC Heart Fail. Published 6 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →