Aortic & peripheral vascular disease
A 4-Decade Population-Based Registry of Thoracic Aortic Dissection Causing Sudden Death in the Young
Authors' conclusion
TAD-related SCD in the young is rare, and TAD is an infrequent cause of SCD, affecting mostly men.
Study context
- Population
- Residents ≤40 years with sudden cardiac death (SCD), Veneto Region, Italy, 1985–2024
- Participants
- 941 SCD cases
- Outcome
- Incidence of TAD-related SCD; prevalence and features of TAD in young SCD
Methodological details4-decade
- 4-decade
Main finding
As reported in the abstract
- Rate of thoracic aortic dissection (TAD)-related SCD (age 1–40 years), 95% CI 0.21-0.46
- 0.32 per 1,000,000
- TAD among SCD (28 of 941)
- 2.9%
- Mean age of TAD cases (years)
- 29.1 ± 7
- Males
- 24
- Type A / type B
- 24 / 4
Observational data: associations, not effects.
Further findings
Clinical features of TAD
- Also chronic TAD
- 7 (29%)
- Symptoms present
- 13 (46%)
- Bicuspid aortic valve (6 early-complex pattern, incl. aortic coarctation in 2)
- 9
- Hypertension
- 5
- Marfan syndrome
- 2
- Pregnancy
- 2
- Isolated aortic coarctation
- 2
- Turner syndrome, previous ductus arteriosus closure, familial TAD, drug abuse
- 1 each
Genetic abnormalities
- Genetic abnormalities in TAD tested
- 8/16 (50%)
- Among screened BAV
- 1/3
Aortic diameter in type A TAD
- Aortic diameters <50 mm in all but 2 cases
Histopathology
- Heterogeneous histopathological pattern
Original publication
A 4-Decade Population-Based Registry of Thoracic Aortic Dissection Causing Sudden Death in the Young. JACC Adv. Published 30 December 2025. doi:10.
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