Aortic & peripheral vascular disease
Safety and Feasibility of Moderate-Intensity Home-Based Guided Exercise in Aortic Dissection Survivors in the United States: A Multicenter Randomized Controlled Trial
Authors' conclusion
In this pilot randomized trial, moderate-intensity home exercise appeared feasible and was not associated with observed excess aortic events compared with usual care. Larger prospective trials are needed to determine long-term effects on cardiovascular outcomes.
Study context
- Population
- Adults ≥3 months post-Type A or B thoracic aortic dissectionrandomized, 65 participants completed all trial milestones
- Participants
- 93 adults
- Comparison
- Guided exercise (GE) vs usual care
- GEn = 44
- Usual care (UC)n = 49
- Primary endpoint
- Coprimary: safety (aortic events, exertional hypertension, symptoms, injury, or events requiring medical care) and Patient-Reported Outcomes Measurement Information System 29-Item Profile scores
Methodological details3 US academic medical centers, pilot
- 3 US academic medical centers
- Pilot
Primary result
As reported in the abstract
- No deaths, aortic operations, or recurrent dissections in either group
- Exertional hypertension in GE was mitigated by exercise modification
- No significant changes in Patient-Reported Outcomes Measurement Information System 29-Item Profile scores (30 GE, 35 UC)
Secondary outcomes
Events
| Outcome | GE | UC |
|---|---|---|
| Loss to follow-up | 5 | 11 |
- Loss to follow-up — Participants lost to follow-up
- Sixteen
- Loss to follow-up — Participants who completed all trial milestones
- 65
Paired ambulatory blood pressure measurements
- No significant changes (25 GE, 28 UC)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Safety and Feasibility of Moderate-Intensity Home-Based Guided Exercise in Aortic Dissection Survivors in the United States: A Multicenter Randomized Controlled Trial. Circ Popul Health Outcomes. Published 2 July 2026. doi:10.
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