Aortic & peripheral vascular disease

Women With Acute Aortic Dissection Have Higher Prehospital Mortality Than Men

JACC AdvPublished Population-based cohort study

Main finding · AAD incidenceResult — go to the resultIncidence rate ratio 0.94 95% CI 0.74–1.20

Authors' conclusion

Women had a higher incidence of AAD presenting as prehospital death than men.

Study context

Population
Patients with incident acute aortic dissection (AAD) in a city of 121,180 residents, 2008–2020
Participants
266 patients
Exposure
Women vs men with AAD
  • Womenn = 137
Outcome
AAD incidence by sex
Methodological detailspostmortem CT data
  • Postmortem CT data

Main finding

AAD incidence

Incidence rate ratio

0.94

95% CI 0.74–1.20

P = 0.64

By group

Womenvs Men
IRR 0.94 (95% CI 0.74–1.20); P = 0.64

As reported in the abstract

Crude AAD incidence (/100,000 person-years)
16.2
Age-adjusted AAD incidence (/100,000 person-years)
14.3

Observational data: associations, not effects.

Further findings

OutcomeWomenMenOR (95% CI)P value
Prehospital mortality37%21%2.24 (1.30–3.87)P = 0.004
AAD among OHCA patients (n = 1,373)11%3.9%2.90 (1.86–4.53)P < 0.001

Age

P < 0.001

Type A AAD

P < 0.001

AAD among out-of-hospital cardiac arrest (OHCA) patients (n = 1,373) — AAD most common in women aged 60 to 69 years
16.4%

Original publication

Women With Acute Aortic Dissection Have Higher Prehospital Mortality Than Men. JACC Adv. Published 3 October 2023. doi:10.1016/j.jacadv.2023.100623

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