Arrhythmias & electrophysiology
A Focal Ablation Catheter Toggling Between Radiofrequency and Pulsed Field Energy to Treat Atrial Fibrillation
Authors' conclusion
AF ablation with a focal RF/PF catheter allows efficient procedures, chronic lesion durability, and good freedom from atrial arrhythmias-for both paroxysmal and persistent AF.
Study context
- Population
- Patients with paroxysmal or persistent atrial fibrillation (AF) undergoing ablation with a focal 9-mm lattice tip catheter (pulsed field ablation (PFA) posteriorly; irrigated radiofrequency ablation (RFA) or PFA anteriorly)paroxysmal/persistent AF = 70/108
- Participants
- 178 patients
- Comparison
- Focal lattice-tip catheter toggling RF/PF ablation, PFA waveform evolution (PULSE1, PULSE2, PULSE3)
- PULSE1n = 76
- PULSE2n = 47
- PULSE3n = 55
- Outcome
- Safety and efficacy of a focal ablation catheter toggling between RFA and PFA
Main finding
As reported in the abstract
Pulmonary vein isolation (PVI) durability at invasive remapping (∼3 months) · ∼3 months postablation
- All lesion sets acutely successful
- 100%
Further findings
1-year Kaplan-Meier freedom from atrial arrhythmias · 1 year (follow-up 348 ± 652 days)
- Paroxysmal AF
- 78.3% ± 5.0%
- Persistent AF
- 77.9% ± 4.1%
- Persistent AF with PULSE3 waveform
- 84.8% ± 4.9%
Safety
Primary adverse events
- Inflammatory pericardial effusion not requiring intervention
- 1
Original publication
A Focal Ablation Catheter Toggling Between Radiofrequency and Pulsed Field Energy to Treat Atrial Fibrillation. JACC Clin Electrophysiol. Published 16 April 2023. doi:10.
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